Colon-targeted protein delivery by using solid lipid nanoparticles

Solid lipid nanoparticles for targeted brain drug delivery.

The present review discusses the potential use of solid lipid nanoparticles for brain drug targeting purposes. The state of the art on surfactant-coated poly(alkylcyanoacrylate) nanoparticles specifically designed for brain targeting is given by emphasizing the transfer of this technology to solid lipid matrices. The available literature on solid lipid nanoparticles and related carriers for bra...

liver targeted delivery of quercetin in hepatocellular carcinoma by phytosterol containing solid lipid nanoparticles

Brain-targeted delivery of resveratrol using solid lipid nanoparticles functionalized with apolipoprotein E

BACKGROUND The present study takes advantage of the beneficial effects of resveratrol as a neuroprotective compound. Resveratrol-loaded solid lipid nanoparticles were functionalized with apolipoprotein E which can be recognized by the LDL receptors overexpressed on the blood-brain barrier. RESULTS Transmission electron microscopy images revealed spherical nanoparticles, dynamic light scatteri...

Oral insulin delivery by means of solid lipid nanoparticles

The aim of this work was to produce and characterize cetyl palmitate-based solid lipid nanoparticles (SLN) containing insulin, and to evaluate the potential of these colloidal carriers for oral administration. SLN were prepared by a modified solvent emulsification-evaporation method based on a w/o/w double emulsion. The particle size, zeta potential and association efficiency of unloaded and in...

Colon Targeted Drug Delivery Using Different Approaches

Although oral delivery has a become a widely accepted route of administration of therapeutic drugs, the gastrointestinal tract presents several formidable barrier to drug delivery. The delivery of drugs to the colon has a number of therapeutic implications in the field of drug delivery. In the recent times, the colon specific drug delivery system is also gaining importance not only for local dr...